Role of tumor microenvironment in cancer progression and therapeutic strategy

Author:

Wang Qingjing1,Shao Xueting2,Zhang Yuxuan1ORCID,Zhu Miaojin3,Wang Frederick X. C.4,Mu Jianjian1,Li Jiaxuan1,Yao Hangping3ORCID,Chen Keda1ORCID

Affiliation:

1. Shulan International Medical College Zhejiang Shuren University Hangzhou China

2. Institute of Pharmaceutical Biotechnology & Research Center for Clinical Pharmacy, The First Affiliated Hospital, School of Medicine Zhejiang University Hangzhou China

3. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine Zhejiang University Hangzhou China

4. The EnMed Program at Houston Methodist Hospital Texas A&M University College of Medicine and College of Engineering Houston Texas USA

Abstract

AbstractCancer is now considered a tumor microenvironment (TME) disease, although it was originally thought to be a cell and gene expression disorder. Over the past 20 years, significant advances have been made in understanding the complexity of the TME and its impact on responses to various anticancer therapies, including immunotherapies. Cancer immunotherapy can recognize and kill cancer cells by regulating the body's immune system. It has achieved good therapeutic effects in various solid tumors and hematological malignancies. Recently, blocking of programmed death‐1 (PD‐1), programmed death‐1 ligand‐1 (PD‐L1), and programmed death Ligand‐2 (PD‐L2), the construction of antigen chimeric T cells (CAR‐T) and tumor vaccines have become popular immunotherapies Tumorigenesis, progression, and metastasis are closely related to TME. Therefore, we review the characteristics of various cells and molecules in the TME, the interaction between PD‐1 and TME, and promising cancer immunotherapy therapeutics.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

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