Embracing ethical research: Implementing the 3R principles into fracture healing research for sustainable scientific progress

Author:

Anup Amritha1,Dieterich Sandra2,Oreffo Richard O. C.3,Dailey Hannah L.4,Lang Annemarie5,Haffner‐Luntzer Melanie2ORCID,Hixon Katherine R.16ORCID

Affiliation:

1. Thayer School of Engineering Dartmouth College Hanover New Hampshire USA

2. Institute of Orthopaedic Research and Biomechanics University Medical Center Ulm Ulm Germany

3. Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, Faculty of Medicine University of Southampton Southampton UK

4. Departments of Orthopaedic Surgery and Bioengineering University of Pennsylvania Philadelphia Pennsylvania USA

5. Department of Mechanical Engineering and Mechanics Lehigh University Bethlehem Pennsylvania USA

6. Geisel School of Medicine Dartmouth College Hanover New Hampshire USA

Abstract

AbstractAs scientific advancements continue to reshape the world, it becomes increasingly crucial to uphold ethical standards and minimize the potentially adverse impact of research activities. In this context, the implementation of the 3R principles—Replacement, Reduction, and Refinement—has emerged as a prominent framework for promoting ethical research practices in the use of animals. This article aims to explore recent advances in integrating the 3R principles into fracture healing research, highlighting their potential to enhance animal welfare, scientific validity, and societal trust. The review focuses on in vitro, in silico, ex vivo, and refined in vivo methods, which have the potential to replace, reduce, and refine animal experiments in musculoskeletal, bone, and fracture healing research. Here, we review material that was presented at the workshop “Implementing 3R Principles into Fracture Healing Research” at the 2023 Orthopedic Research Society (ORS) Annual Meeting in Dallas, Texas.

Funder

Orthopaedic Trauma Association

Division of Civil, Mechanical and Manufacturing Innovation

Publisher

Wiley

Subject

Orthopedics and Sports Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3