<scp>SLC40A1</scp> in iron metabolism, ferroptosis, and disease: A review-Reference-Cited by-同舟云学术

SLC40A1 in iron metabolism, ferroptosis, and disease: A review

Published:2024-03-20 Issue:4 Volume:16 Page:
ISSN:2692-9368
Container-title:WIREs Mechanisms of Disease
language:en
Short-container-title:WIREs Mechanisms of Disease

Author:

Zhang Yan¹^ORCID,Zou Liyi²,Li Xiaodan³,Guo Long¹,Hu Baoguang⁴,Ye Hua¹,Liu Yi¹

Affiliation:

1. Guangdong Key Laboratory for Research and Development of Natural Drugs, School of Pharmacy Guangdong Medical University Zhanjiang Guangdong China

2. Guangdong Key Laboratory for Research and Development of Natural Drugs, School of Pharmacy Guangdong Medical University Dongguan Guangdong China

3. People's Hospital of Longhua District Shenzhen Guangdong China

4. Department of Gastrointestinal Surgery Binzhou Medical University Hospital Binzhou Shandong China

Abstract

AbstractSolute carrier family 40 member 1 (SLC40A1) plays an essential role in transporting iron from intracellular to extracellular environments. When SLC40A1 expression is abnormal, cellular iron metabolism becomes dysregulated, resulting in an overload of intracellular iron, which induces cell ferroptosis. Numerous studies have confirmed that ferroptosis is closely associated with the development of many diseases. Here, we review recent findings on SLC40A1 in ferroptosis and its association with various diseases, intending to explore new directions for research on disease pathogenesis and new therapeutic targets for prevention and treatment.This article is categorized under:

Cancer > Genetics/Genomics/Epigenetics

Metabolic Diseases > Molecular and Cellular Physiology

Funder

Natural Science Foundation of Guangdong Province

Publisher

Wiley

Link

https://wires.onlinelibrary.wiley.com/doi/pdf/10.1002/wsbm.1644

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