Impact of Acid-Reducing Agents on the Pharmacokinetics of Palbociclib, a Weak Base With pH-Dependent Solubility, With Different Food Intake Conditions
Author:
Affiliation:
1. Pfizer Inc; San Diego CA USA
2. Pfizer Inc; Groton CT USA
3. Pfizer Inc; New Haven CT USA
4. Pfizer Inc; Collegeville PA USA
Funder
Pfizer
Publisher
Wiley
Subject
Pharmacology (medical),Pharmaceutical Science
Reference30 articles.
1. Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development;Smelick;Mol Pharm,2013
2. Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of targeted therapy?;Budha;Clin Pharmacol Ther,2012
3. Drug-drug interactions with tyrosine-kinase inhibitors: a clinical perspective;Leeuwen;Lancet Oncol,2014
4. Phase I study of the effect of gastric acid pH modulators on the bioavailability of oral dasatinib in healthy subjects;Eley;J Clin Pharmacol,2009
5. Effect of gastric pH on erlotinib pharmacokinetics in healthy individuals: omeprazole and ranitidine;Kletzl;Anticancer Drugs,2015
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