An Integrated Approach for Fragment-Based Lead Discovery: Virtual, NMR, and High-Throughput Screening Combined with Structure-Guided Design. Application to the Aspartyl Protease Renin.

Author:

Rüdisser Simon,Vangrevelinghe Eric,Maibaum Jürgen

Publisher

Wiley-VCH Verlag GmbH & Co. KGaA

Reference120 articles.

1. Experiences in fragment-based drug discovery;Murray;Trends in Pharmacological Sciences,2012

2. Fragment-based lead discovery grows up;Baker;Nature Reviews Drug Discovery,2013

3. Fragment based drug design: from experimental to computational approaches;Kumar;Current Medicinal Chemistry,2012

4. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery;Leonardo;Proceedings of the National Academy of Sciences of the United States of America,2013

5. Fragment-based screening by biochemical assays: systematic feasibility studies with trypsin and MMP12;Boettcher;Journal of Biomolecular Screening,2010

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Biophysical screening in fragment-based drug design: a brief overview;Bioscience Horizons: The International Journal of Student Research;2018-01-01

2. Twenty years on: the impact of fragments on drug discovery;Nature Reviews Drug Discovery;2016-07-15

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