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Merged Multiple Ligands

Published:2017-12-08 Issue: Volume: Page:247-274
ISSN:1865-0562
Container-title:Methods and Principles in Medicinal Chemistry
language:
Short-container-title:

Author:

Chen Hongming¹,Bauer Udo²,Engkvist Ola¹

Affiliation:

1. Discovery Sciences, Innovative Medicines and Early Development; AstraZeneca; Pepparedsleden 1 431 83 Mölndal Sweden

2. Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development; AstraZeneca; Pepparedsleden 1 431 83 Mölndal Sweden

Publisher

Wiley-VCH Verlag GmbH & Co. KGaA

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/9783527674381.ch9/fullpdf

Reference68 articles.

1. The physicochemical challenges of designing multiple ligands;Morphy;J. Med. Chem.,2006

2. From magic bullets to designed multiple ligands;Morphy;Drug Discovery Today,2004

3. Network pharmacology: the next paradigm in drug discovery;Hopkins;Nat. Chem. Biol.,2008

4. From in silico target prediction to multi-target drug design: current databases, methods and applications;Koutsoukas;J. Proteomics,2011

5. The protein data bank;Berman;Nucleic Acids Res.,2000

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1. Polypharmacology: The science of multi-targeting molecules;Pharmacological Research;2022-02

2. Recent Progress on Tubulin Inhibitors with Dual Targeting Capabilities for Cancer Therapy;Journal of Medicinal Chemistry;2021-06-08

3. Polypharmacology by Design: A Medicinal Chemist’s Perspective on Multitargeting Compounds;Journal of Medicinal Chemistry;2018-07-23

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