Benzimidazole-Based H+/K+-ATPase Inhibitors for the Treatment of Gastroesophageal Reflux Disease
Author:
Publisher
Wiley-VCH Verlag GmbH & Co. KGaA
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/9783527664450.ch19/fullpdf
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1. Omeprazole: The first proton pump inhibitor
2. Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase
3. (H+, K+)-ATPase inhibiting 2-[(2-pyridylmethyl)sulfinyl]benzimidazoles. 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The selection of pantoprazole as a clinical candidate
4. Gastroprotective activity of the novel proton pump inhibitor lansoprazole in the rat
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