The Case for an Unblinded Modeler in Early Clinical Development

Author:

Krause Andreas1,Henrich Andrea1,Dingemanse Jasper1

Affiliation:

1. Idorsia Pharmaceuticals Ltd Clinical Pharmacology Allschwil Switzerland

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference34 articles.

1. Impact of Pharmacometric Analyses on New Drug Approval and Labelling Decisions

2. Impact of Pharmacometric Reviews on New Drug Approval and Labeling Decisions—a Survey of 31 New Drug Applications Submitted Between 2005 and 2006

3. Impact of Pharmacometric Analyses on New Drug Approval and Labelling Decisions

4. European Medicines Agency Committee for Medicinal Products for Human Use (CHMP).Guideline on strategies to identify and mitigate risks for first‐in‐human and early clinical trials with investigational medicinal products.https://www.ema.europa.eu/documents/scientific-guideline/guideline-strategies-identify-mitigate-risks-first-human-early-clinical-trials-investigational_en.pdf. Published July 20 2017. Accessed September 17 2019.

5. Estimating the starting dose for entry into humans: principles and practice

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