Appendectomy and the Risk of Parkinson's Disease: A Korean Nationwide Study

Author:

Park Kye Won1,Woo Hyeong Taek2,Hwang Yun Su3,Lee Seung Hyun4,Chung Sun Ju5ORCID

Affiliation:

1. Pacific Parkinson Research Centre University of British Columbia Vancouver British Columbia Canada

2. Department of Preventive Medicine Keimyung University School of Medicine Daegu Korea

3. Department of Neurology Jeonbuk National University Medical School and Hospital Jeonju Korea

4. Department of Neurology Seoul Medical Center Seoul Korea

5. Department of Neurology, Asan Medical Center University of Ulsan College of Medicine Seoul Korea

Abstract

AbstractBackgroundThe vermiform appendix is considered a potential reservoir for the abnormal α‐synuclein aggregate in Parkinson's disease (PD). Previous epidemiologic evidence on the association between appendectomy and PD risk remains inconclusive, especially outside the Western world.ObjectivesTo investigate the association between appendectomy and PD risk in Korea.MethodsAmong 703,831 eligible adult subjects in the National Health Insurance Service sample cohort, we identified 16,122 patients who underwent appendectomy. The rest formed the control group. PD risk was assessed using time‐dependent Cox regression analyses.ResultsThe appendectomy group did not have altered risk of PD compared with the control group in either unadjusted [hazard ratio (HR) 1.32, 95% confidence interval (CI) 0.97–1.80, P = 0.08] or adjusted model (HR 1.42, CI 0.88–2.30, P = 0.15). No further statistical difference appeared when stratified by sex.ConclusionsAppendectomy is not associated with altered risk of PD in the Korean population.

Funder

Asan Institute for Life Sciences, Asan Medical Center

Publisher

Wiley

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