Evaluation of Transport Mechanism of Prodrugs and Parent Drugs Formed by Intracellular Metabolism in Caco-2 Cells with Modified Carboxylesterase Activity: Temocapril as a Model Case-Reference-Cited by-同舟云学术

Evaluation of Transport Mechanism of Prodrugs and Parent Drugs Formed by Intracellular Metabolism in Caco-2 Cells with Modified Carboxylesterase Activity: Temocapril as a Model Case

Published:2011-09 Issue:9 Volume:100 Page:3985-3994
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Ohura Kayoko,Nozawa Takaaki,Murakami Koichi,Imai Teruko

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference41 articles.

1. Caco-2 monolayers in experimental and theoretical predictions of drug transport;Artursson;Adv Drug Deliv Rev,2001

2. Human intestinal permeability;Lennernäs;J Pharm Sci,1998

3. Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3;Schmiedlin-Ren;Mol Pharmacol,1997

4. Identification of esterases expressed in Caco-2 cells and effects of their hydrolyzing activity in predicting human intestinal absorption;Imai;Drug Metab Dispos,2005

5. Current progress on esterases: from molecular structure to function;Satoh;Drug Metab Dispos,2002

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