Affiliation:
1. Institute of Medical Biometry and Epidemiology University Medical Center Hamburg‐Eppendorf Hamburg Germany
Abstract
AbstractSince the introduction of the estimand in therapeutical studies, several adaptions have been developed. This short article highlights the important aspects of the estimand concept. A literature research was conducted to identify different extensions to this framework. Different modified strategies for intercurrent events are presented, as well as examples of methods to implement the estimand in clinical studies. The article reflects that the estimand is an ongoing research field with further exploration.
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