Oral hard tissue defect models for evaluating the regenerative efficacy of implant materials

Author:

Sun Xiaowen1,Heng Boon Chin23,Zhang Xuehui14ORCID

Affiliation:

1. Department of Dental Materials & Dental Medical Devices Testing Center Peking University School and Hospital of Stomatology Beijing People's Republic of China

2. Central Laboratory Peking University School and Hospital of Stomatology Beijing People's Republic of China

3. School of Medical and Life Sciences Sunway University Darul Ehsan Selangor Malaysia

4. National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, NMPA Key Laboratory for Dental Materials, Beijing Laboratory of Biomedical Materials & Beijing Key Laboratory of Digital Stomatology Peking University School and Hospital of Stomatology Beijing People's Republic of China

Abstract

AbstractOral hard tissue defects are common concomitant symptoms of oral diseases, which have poor prognosis and often exert detrimental effects on the physical and mental health of patients. Implant materials can accelerate the regeneration of oral hard tissue defects (such as periodontal defects, alveolar bone defects, maxilla bone defects, mandible bone defects, alveolar ridge expansion, and site preservation), but their regenerative efficacy and biocompatibility need to be preclinically validated in vivo with animal‐based oral hard tissue defect models. The choice of oral hard tissue defect model depends on the regenerative effect and intended application of the tested implant material. At the same time, factors that need to be considered include techniques for constructing the particular defect model, the scaffold/graft material used, the availability of animal model evaluation techniques and instrumentation, as well as costs and time constraints. In this article, we summarize the common oral hard tissue defect models in various animal species (such as periodontal model, jaw defect model, and implantation defect model) that can be used to evaluate the regenerative efficacy and biocompatibility of implant materials.

Publisher

Wiley

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