Molecular binding scaffolds increase local substrate concentration enhancing the enzymatic hydrolysis of VX nerve agent-Reference-Cited by-同舟云学术

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Molecular binding scaffolds increase local substrate concentration enhancing the enzymatic hydrolysis of VX nerve agent

Published:2020-04-16 Issue:7 Volume:117 Page:1970-1978
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnology and Bioengineering

Author:

Lang Xuye¹,Hong Xiao²,Baker Cetara A.³,Otto Tamara C.³,Wheeldon Ian¹⁴^ORCID

Affiliation:

1. Chemical and Environmental Engineering Department University of California Riverside California

2. Biochemistry Department University of California Riverside California

3. U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground Aberdeen Maryland

4. Center for Industrial Biotechnology University of California Riverside California

Funder

Defense Threat Reduction Agency

Army Research Office

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27346

Reference37 articles.

1. Enzymatic Neutralization of the Chemical Warfare Agent VX: Evolution of Phosphotriesterase for Phosphorothiolate Hydrolysis

2. Understanding How Nanoparticle Attachment Enhances Phosphotriesterase Kinetic Efficiency

3. Assembling high activity phosphotriesterase composites using hybrid nanoparticle peptide-DNA scaffolded architectures

4. Investigation of diffusion-limited rates of chymotrypsin reactions by viscosity variation

5. Hydrogel‐Immobilized Supercharged Proteins

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1. Enhancing enzymatic activity with nanoparticle display – an updated compendium and engineering outlook;Molecular Systems Design & Engineering;2024

2. Multienzymatic Cascades and Nanomaterial Scaffolding—A Potential Way Forward for the Efficient Biosynthesis of Novel Chemical Products;Advanced Materials;2023-11-29

3. Reversal of Catalytic Material Substrate Selectivity through Partitioning of Polymers in Hierarchically Ordered Virus-like Particle Frameworks;Chemistry of Materials;2023-10-20

4. DNA nanotechnology-based biomolecular assembly and imaging;Chinese Science Bulletin;2023-08-17

5. Multiscale simulation-guided design of enzyme bioconjugates with enhanced catalysis;Chem Catalysis;2022-10

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