Tailoring translational strength using Kozak sequence variants improves bispecific antibody assembly and reduces product‐related impurities in CHO cells-Reference-Cited by-同舟云学术

Tailoring translational strength using Kozak sequence variants improves bispecific antibody assembly and reduces product‐related impurities in CHO cells

Published:2020-04-21 Issue:7 Volume:117 Page:1946-1960
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnology and Bioengineering

Author:

Blanco Noelia¹^ORCID,Williams Ambrose J.²,Tang Danming¹,Zhan Dejin¹,Misaghi Shahram¹^ORCID,Kelley Robert F.³,Simmons Laura C.¹

Affiliation:

1. Departments of Cell CultureGenentech, Inc., 1 DNA Way South San Francisco California

2. Departments of Purification DevelopmentGenentech, Inc., 1 DNA Way South San Francisco California

3. Departments of Drug DeliveryGenentech, Inc., 1 DNA Way South San Francisco California

Funder

Genentech

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27347

Reference64 articles.

1. Changes in global translation elongation or initiation rates shape the proteome via the Kozak sequence

2. Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library

3. Coming-of-Age of Antibodies in Cancer Therapeutics

4. Optimizing antibody expression: The nuts and bolts

5. The making of bispecific antibodies

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Metabolic Engineering of Saccharomyces cerevisiae for High-Level Production of l-Pipecolic Acid from Glucose;ACS Synthetic Biology;2024-09-12

2. Optimization of extended Kozak elements enhances recombinant proteins expression in CHO cells;Journal of Biotechnology;2024-09

3. Facilitating secretory expression of apple seed β‐glucosidase in Komagataella phaffii for the efficient preparation of salidroside;Biotechnology Journal;2024-08

4. Development of a 10 g/L process for a difficult-to-express multispecific antibody format using a holistic process development approach;Journal of Biotechnology;2024-06

5. Decoupled degradation and translation enables noise modulation by poly(A) tails;Cell Systems;2024-06