Predictions of Systemic, Intracellular, and Lung Concentrations of Azithromycin With Different Dosing Regimens Used in COVID‐19 Clinical Trials

Author:

Hughes Jim H.1,Sweeney Kevin1,Ahadieh Sima1,Ouellet Daniele12

Affiliation:

1. Pfizer Global Research and Development Groton Connecticut USA

2. Pfizer Global Research and Development Collegeville Pennsylvania USA

Funder

Pfizer

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Reference25 articles.

1. Hydroxychloroquine and azithromycin as a treatment of COVID‐19: results of an open‐label non‐randomized clinical trial;Gautret P.;Int. J. Antimibrob. Agents

2. Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID‐19 patients with at least a six‐day follow up: an observation study;Gautret P.;Travel Med. Infect. Dis.

3. Clinical pharmacology perspectives on the antiviral activity of azithromycin and use in COVID‐19;Damle B.;Clin. Pharmacol. Therapeut

4. Touret F.et al.In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS‐CoV‐2 replication. bioRxiv. 10.1101/2020.04.03.023846. [epub ahead of print].

5. Development of a Population Pharmacokinetic Model Characterizing the Tissue Distribution of Azithromycin in Healthy Subjects

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