In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren-Reference-Cited by-同舟云学术

In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren

Published:2020-03-20 Issue:2 Volume:8 Page:
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol Res Perspect

Author:

Kong Ronald¹^ORCID,Ma Jiyuan¹,Hwang Seongwoo¹,Moon Young‐Choon¹,Welch Ellen M.¹,Weetall Marla¹,Colacino Joseph M.¹,Almstead Neil¹,Babiak John¹,Goodwin Elizabeth¹

Affiliation:

1. PTC Therapeutics, Inc. South Plainfield NJ USA

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.576

Reference36 articles.

1. Ataluren as an Agent for Therapeutic Nonsense Suppression

2. PTC124 targets genetic disorders caused by nonsense mutations

3. Nonsense suppression activity of PTC124 (ataluren)

4. Read-through compound 13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy

5. Phase 2a Study of Ataluren-Mediated Dystrophin Production in Patients with Nonsense Mutation Duchenne Muscular Dystrophy

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2. A mass defect filtering combined background subtraction strategy for rapid screening and identification of metabolites in rat plasma after oral administration of Yindan Xinnaotong soft capsule;Journal of Pharmaceutical and Biomedical Analysis;2023-07

3. In Vitro Metabolism, Pharmacokinetics and Drug Interaction Potentials of Emvododstat, a DHODH Inhibitor;Xenobiotica;2021-11-30

4. A Novel System for Evaluating the Inhibition Effect of Drugs on Cytochrome P450 Enzymes in vitro Based on Human-Induced Hepatocytes (hiHeps);Frontiers in Pharmacology;2021-10-28

5. Ataluren—Promising Therapeutic Premature Termination Codon Readthrough Frontrunner;Pharmaceuticals;2021-08-09