Intramolecular cyclization of the antimicrobial peptide Polybia-MPI with triazole stapling: influence on stability and bioactivity

Author:

Liu Beijun12ORCID,Zhang Wei1,Gou Sanhu1,Huang Haifeng3,Yao Jia4,Yang Zhibin5,Liu Hui2,Zhong Chao2,Liu Beiyin6,Ni Jingman12,Wang Rui1ORCID

Affiliation:

1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences; Lanzhou University; Lanzhou 730000 China

2. School of Pharmacy; Lanzhou University; Lanzhou 730000 China

3. Shaanxi Provincial People's Hospital; Shanxi 710068 China

4. The First Hospital of Lanzhou University; 199 West Donggang Road Lanzhou 730000 China

5. Key Laboratory of Entomological Biopharmaceutical R&D of Yunnan Province; Dali University; Dali 671000 China

6. Affiliated Hospital of Gansu University of Chinese Medicine; Lanzhou 730000 China

Funder

National Natural Science Foundation of China

the National Natural Science Foundation of China

the Natural Science Foundation of Gansu Province

Program for Changjiang Scholars and Innovative Research Team in University

the Key National S&T Program of the Ministry of Science and Technology

Publisher

Wiley

Subject

Organic Chemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry,Structural Biology

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