Risk of QT prolongation and torsade de pointes associated with exposure to hydroxyzine: re-evaluation of an established drug

Author:

Schlit Anne-Françoise1,Delaunois Annie1,Colomar Aurore1,Claudio Branderley2,Cariolato Luca2,Boev Rossen3,Valentin Jean-Pierre1,Peters Christopher1,Sloan Victor S.4,Bentz Jürgen W. G.1

Affiliation:

1. UCB Pharma; Brussels Belgium

2. UBC; Geneva Switzerland

3. UCB Pharma; Bulle Switzerland

4. UCB Pharma; Raleigh North Carolina USA

Funder

UCB Pharma

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Reference38 articles.

1. QT interval prolongation and torsade de pointes: synergistic effect of flecainide and H1 receptor antagonists;Acosta-Materan;J. Pharmacol. Pharmacother.,2016

2. Atarax Summary of Product Characteristics 2016 https://www.medicines.org.uk/emc/medicine/1455

3. Acquired Long QT Syndrome

4. QT-interval parameters are increased in systemic lupus erythematosus patients;Cardoso;Lupus,2005

5. Effect of H1 antihistamines upon the cardiovascular system;Davila;J Investig Allergol Clin Immunol,2006

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