Determination of low levels of 2 H-labeling using high-resolution mass spectrometry: Application in studies of lipid flux and beyond

Author:

Herath Kithsiri B.1,Zhong Wendy1,Yang Jiong1,Mahsut Ablatt1,Rohm Rory J.1,Shah Vinit1,Castro-Perez Jose1,Zhou Haihong1,Attygalle Athula B.2,Kang Ling1,Singh Sheo1,Johns Douglas G.1,Cleary Michele A.1,Hubbard Brian K.1,Previs Stephen F.1,Roddy Thomas P.1

Affiliation:

1. Merck Research Laboratories; Rahway NJ USA

2. Department of Chemistry, Chemical Biology and Biomedical Engineering; Stevens Institute of Technology; Hoboken NJ USA

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Analytical Chemistry

Reference19 articles.

1. In vivo study of the biosynthesis of long-chain fatty acids using deuterated water;Ajie;Am. J. Physiol.,1995

2. Measurement of triglyceride synthesis in humans using deuterium oxide and isotope ratio mass spectrometry;Leitch;Biol. Mass Spectrom.,1991

3. Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: use of simple gas chromatographic/mass spectrometric techniques;Diraison;J. Mass Spectrom.,1997

4. The role of naturally occurring stable isotopes in mass spectrometry, part I: The theory;Bluck;Spectroscopy,2008

5. Applications of mass isotopomer analysis to nutrition research;Brunengraber;Annu. Rev. Nutr.,1997

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