Nanolobatone A, An Unprecedented Diterpenoid and Related New Casbanoids from the Hainan Soft Coral <i>Sinularia nanolobata</i>-Reference-Cited by-同舟云学术

Nanolobatone A, An Unprecedented Diterpenoid and Related New Casbanoids from the Hainan Soft Coral Sinularia nanolobata

Published:2023-03-22 Issue:26 Volume:29 Page:
ISSN:0947-6539
Container-title:Chemistry – A European Journal
language:en
Short-container-title:Chemistry A European J

Author:

Liu Jiao¹²,Li Song‐Wei³,Zhao Qing‐Min¹²,Zhang Zai‐Yong¹,Yao Li‐Gong¹,Gu Yu‐Cheng⁴,Lan Le‐Fu¹²,Guo Yue‐Wei¹²⁵^ORCID

Affiliation:

1. State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park Shanghai 201203 P. R. China

2. University of Chinese Academy of Sciences No. 19 A Yuquan Road Beijing 100049 P. R. China

3. College of Pharmaceutical Science Zhejiang University of Technology No. 18 Chaowang Road Hangzhou 310014 P. R. China

4. Jealott's Hill International Research Centre Syngenta Bracknell Berkshire RG42 6EY UK

5. Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery Yantai Shandong 264117 P. R. China

Abstract

AbstractNanolobatone A, featuring an unprecedented tricyclo[10.3.0.01,2]pentadecane carbon skeleton, along with four new polyoxygenated and four unusual endoperoxide‐bridged casbane‐type diterpenoids were isolated from the Hainan soft coral Sinularia nanolobata. The structures of the new compounds were established by extensive spectroscopic analysis, X‐ray diffraction analysis, and time‐dependent density functional theory/electronic circular dichroism calculations. A plausible biosynthetic pathway of new isolates was proposed. Bioassays revealed that nanolobatone A showed weak antibacterial activity against the Gram‐positive bacteria Streptococcus pyogenes.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/chem.202300055

Reference48 articles.

2. Terpenoids of Sinularia soft corals: chemistry and bioactivity

3. Chemical Diversity and Biological Activity of Secondary Metabolites from Soft Coral Genus Sinularia since 2013

4. Cubitanoids and Cembranoids from the Soft Coral Sinularia nanolobata

5. Sinulobatins A ∼ D, new amphilectane-type diterpenoids from the Japanese soft coral Sinularia nanolobata

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