Remote Electronic Effect of Chiral N‐Heterocyclic Carbene Catalyst on an Asymmetric Benzoin Reaction-Reference-Cited by-同舟云学术

Remote Electronic Effect of Chiral N‐Heterocyclic Carbene Catalyst on an Asymmetric Benzoin Reaction

Published:2023-05-17 Issue:38 Volume:29 Page:
ISSN:0947-6539
Container-title:Chemistry – A European Journal
language:en
Short-container-title:Chemistry A European J

Author:

Inokuma Tsubasa¹²,Hashimoto Kentaro¹,Fujiwara Tatsuya¹,Sun Chunzhao¹,Kuwano Satoru³,Yamada Ken‐ichi¹²^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences Tokushima University Shomachi Tokushima 770-8505 Japan

2. Research Cluster on “Key Material Development” Tokushima University Shomachi Tokushima 770-8505 Japan

3. Graduate School of Pharmaceutical Sciences Kyoto University Yoshida, Sakyo-ku Kyoto 606-8501 Japan

Abstract

AbstractA remote electronic effect of chiral aminoindanol‐derived N‐heterocyclic carbene catalyst on an asymmetric benzoin reaction was investigated. The catalyst bearing remote electron‐withdrawing substituents increased enantioselectivity of the reaction at the cost of the reaction rate. DFT calculations rationalized the increased enantioselectivity.

Funder

Japan Society for the Promotion of Science

Mochida Memorial Foundation for Medical and Pharmaceutical Research

University of Tokushima

Japan Science Society

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

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