Affiliation:
1. College of Chemistry and Chemical Engineering Qingdao University NingXia Road 308# Qingdao 266071 China
Abstract
AbstractAtropisomers have emerged as important structural scaffolds in natural products, drug design, and asymmetric synthesis. Recently, N−N biaryl atropisomers have drawn increasing interest due to their unique structure and relatively stable axes. However, its asymmetric synthesis remains scarce compared to its well‐developed C−C biaryl analogs. In this concept, we summarize the asymmetric synthesis of N−N biaryl atropisomers including N−N pyrrole−pyrrole, N−N pyrrole−indole, N−N indole−indole, and N−N indole−carbazole, during which a series synthetic strategies are highlighted. Also, a synthetic evolution is briefly reviewed and an outlook of N−N biaryl atropisomers synthesis is offered.
Funder
Taishan Scholar Foundation of Shandong Province
National Natural Science Foundation of China
Natural Science Foundation of Shandong Province
Subject
General Chemistry,Catalysis,Organic Chemistry
Cited by
2 articles.
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