Gas Delivery Relevant to Human Health using Porous Materials

Author:

Mandel Ruth M.1ORCID,Lotlikar Piyusha S.12,Keasler Kaitlyn T.1ORCID,Chen Elena Y.1,Wilson Justin J.12,Milner Phillip J.1ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology Cornell University 14853 Ithaca, NY United States

2. Department of Chemistry and Biochemistry University of California, Santa Barbara 93106 Santa Barbara, CA United States

Abstract

AbstractGases are essential for various applications relevant to human health, including in medicine, biomedical imaging, and pharmaceutical synthesis. However, gases are significantly more challenging to safely handle than liquids and solids. Herein, we review the use of porous materials, such as metal‐organic frameworks (MOFs), zeolites, and silicas, to adsorb medicinally relevant gases and facilitate their handling as solids. Specific topics include the use of MOFs and zeolites to deliver H2S for therapeutic applications, 129Xe for magnetic resonance imaging, O2 for the treatment of cancer and hypoxia, and various gases for use in organic synthesis. This Perspective aims to bring together the organic, inorganic, medicinal, and materials chemistry communities to inspire the design of next‐generation porous materials for the storage and delivery of medicinally relevant gases.

Funder

National Institutes of Health

National Science Foundation

Camille and Henry Dreyfus Foundation

Publisher

Wiley

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