Affiliation:
1. College of Chemistry and Chemical Engineering, State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan University Changsha 410082 P. R. China
2. College of Chemistry and Molecular Sciences Institute for Advanced Studies IAS) Wuhan University Wuhan, Hubei 430072 P. R. China
Abstract
AbstractDecarboxylative cross‐coupling reactions are powerful tools for carbon‐heteroatom bonds formation, but typically require pre‐activated carboxylic acids as substrates or heteroelectrophiles as functional groups. Herein, we present an electrochemical decarboxylative cross‐coupling of carboxylic acids with structurally diverse fluorine, alcohol, H2O, acid, and amine as nucleophiles. This strategy takes advantage of the ready availability of these building blocks from commercial libraries, as well as the mild and oxidant‐free conditions provided by electrochemical system. This reaction demonstrates good functional‐group tolerance and its utility in late‐stage functionalization.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Hunan Province