Affiliation:
1. Department of Chemistry Ludwig-Maximilians University Butenandtstraße 5–13, Haus F 81377 Munich Germany
2. Research & Development Syngenta Crop Protection AG Schaffhauserstrasse 101 4332 Stein Switzerland
Abstract
AbstractWe described a regioselective tri‐ and tetra‐functionalization of the pyridazine scaffold using two readily available building blocks: 3‐alkylthio‐6‐chloropyridazine and 3,4‐bis(methylthio)‐6‐chloropyridazine by performing selective metalations with TMPMgCl ⋅ LiCl and catalyst‐tuned cross‐coupling reactions with arylzinc halides. Several of the resulting pyridazines were converted into more elaborated N‐heterocycles such as thieno[2,3‐c]pyridazines and 1H‐pyrazolo[3,4‐c]pyridazines.
Subject
General Chemistry,Catalysis,Organic Chemistry