Affiliation:
1. State Key Laboratory of Chemical Biology Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China
2. Institute of Translational Medicine Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China
Abstract
AbstractChemical synthesis of an orthogonally protected hexasaccharide relevant to the reducing‐end half of axinelloside A, a highly sulfated marine lipopolysaccharide, is disclosed. The synthesis features preparation of the scyllo‐inositol unit via a Ferrier‐type‐II rearrangement, construction of the 1,2‐cis‐glycosidic bonds via remote participation, and concise [2+2+2] assembly via Au(I)‐catalyzed glycosylation.
Funder
National Natural Science Foundation of China
Subject
General Chemistry,Catalysis,Organic Chemistry