Affiliation:
1. Key Laboratory of Green and Precise Synthetic Chemistry and Applications Ministry of Education School of Chemistry and Materials Science Huaibei Normal University Huaibei 235000 Anhui P.R. China
2. Key Laboratory of Functional Molecular Solids Ministry of Education Anhui Key Laboratory of Chemo/Biosensing College of Chemistry and Materials Science Anhui Normal University Wuhu 241000 P.R. China
Abstract
AbstractSolid‐state glass nanopipettes provide a promising confined space that offers several advantages such as controllable size, simple preparation, low cost, good mechanical stability, and good thermal stability. These advantages make them an ideal choice for various applications such as biosensors, DNA sequencing, and drug delivery. In this review, we first delve into the functionalized nanopipettes for sensing various analytes and the methods used to develop detection means with them. Next, we provide an in‐depth overview of the advanced functionalization methodologies of nanopipettes based on diversified chemical kinetics. After that, we present the latest state‐of‐the‐art achievements and potential applications in detecting a wide range of targets, including ions, molecules, biological macromolecules, and single cells. We examine the various challenges that arise when working with these targets, as well as the innovative solutions developed to overcome them. The final section offers an in‐depth overview of the current development status, newest trends, and application prospects of sensors. Overall, this review provides a comprehensive and detailed analysis of the current state‐of‐the‐art functionalized nanopipette perception sensing and development of detection means and offers valuable insights into the prospects for this exciting field.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Anhui Province