HPLC‐Based Automated Synthesis and Purification of Carbohydrates-Reference-Cited by-同舟云学术

HPLC‐Based Automated Synthesis and Purification of Carbohydrates

Published:2024-05-29 Issue:43 Volume:30 Page:
ISSN:0947-6539
Container-title:Chemistry – A European Journal
language:en
Short-container-title:Chemistry A European J

Author:

Kashiwagi Gustavo A.¹^ORCID,Petrosilli Laura¹²^ORCID,Escopy Samira¹³^ORCID,Lay Luigi²^ORCID,Stine Keith J.³^ORCID,De Meo Cristina⁴,Demchenko Alexei V.¹^ORCID

Affiliation:

1. Department of Chemistry Saint Louis University 3501Laclede Ave St. Louis, Missouri 63103 USA

2. Department of Chemistry University of Milan Via Golgi 19 Milan 20133 Italy

3. Department of Chemistry and Biochemistry University of Missouri St. Louis, One University Boulevard St. Louis, Missouri 63121 USA

4. Department of Chemistry Southern Illinois University Edwardsville 1 Hairpin Dr. Edwardsville, Illinois 62025 USA

Abstract

AbstractReported herein is a new HPLC‐based automated synthesizer (HPLC−A) capable of a temperature‐controlled synthesis and purification of carbohydrates. The developed platform allows to perform various protecting group manipulations as well as the synthesis of O‐ and N‐glycosides. A fully automated synthesis and purification was showcased in application to different carbohydrate derivatives including glycosides, oligosaccharides, glycopeptides, glycolipids, and nucleosides.

Funder

National Institute of General Medical Sciences

Publisher

Wiley

Reference93 articles.

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2. Novel Strategy to Release and Tag N-Glycans for Functional Glycomics

4. Toward Automated Enzymatic Synthesis of Oligosaccharides

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