Synthesis and Biological Evaluation of Simplified Ansellone Analogues with Lipophilic Side Chains as HIV Latency‐Reversing Agents-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of Simplified Ansellone Analogues with Lipophilic Side Chains as HIV Latency‐Reversing Agents

Published:2023-07-06 Issue:44 Volume:29 Page:
ISSN:0947-6539
Container-title:Chemistry – A European Journal
language:en
Short-container-title:Chemistry A European J

Author:

Yanagihara Mizushi¹,Kishimoto Naoki²,Nakahara Kanae¹,Abe Towa²,Miura Satoshi²,Lin Bangzhong¹,Fumimoto Megumi¹,Haruta Junichi¹,Misumi Shogo²,Arisawa Mitsuhiro¹^ORCID,Murai Kenichi¹^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences Osaka University Suita Osaka 565-0871 Japan

2. Department of Environmental and Molecular Health Sciences Faculty of Medical and Pharmaceutical Sciences Kumamoto University Kumamoto 862-0973 Japan

Abstract

AbstractStructurally simplified analogues of ansellone A, in which the decalin skeleton is replaced with a lipophilic chain, were prepared and their HIV latency‐reversing activities biologically evaluated. In particular, two analogues bearing ether and alkenyl side chains, respectively, showed comparable activities to that of ansellone A. Each of the simplified compounds was easily synthesized using Prins cyclisation chemistry.

Funder

Japan Society for the Promotion of Science

Takeda Science Foundation

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Reference53 articles.

1. For reviews see

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3. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

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