Affiliation:
1. School of Chemistry and Chemical Engineering Liaocheng University 1 Hunan Avenue Liaocheng 252000 Shandong P. R. China
2. State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology E-208 West Campus 2 Ling Gong Road Dalian 116024 P. R. China
3. College of Chemistry and Life Sciences Zhejiang Normal University 688 Yingbin Avenue Jinhua 321004 P. R. China
Abstract
AbstractThe room temperature metal‐free cascade electrophilic addition/cyclization/oxidation reactions of (3‐phenoxyprop‐1‐yn‐1‐yl)benzenes to divergently synthesize various brominated benzopyran derivatives (3‐bromo‐2H‐chromenes, 3‐bromo‐2H‐chromen‐2‐ols and 3‐bromo coumarins) by tuning the amount of Br2 and H2O have been developed. The method exhibited high selectivity, mild reaction conditions, broad substrate scope, high efficiency, and the applicability for derivatization of the brominated products. The importance of the strategies provides a great advantage for selective synthesis of brominated benzopyran derivatives.
Funder
National Natural Science Foundation of China