Intermolecular Dearomative 1,2‐Amination/Carbonylation via Nucleophilic Addition of Simple Amines to Arene π‐Bonds
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Published:2023-05-08
Issue:36
Volume:29
Page:
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ISSN:0947-6539
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Container-title:Chemistry – A European Journal
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language:en
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Short-container-title:Chemistry A European J
Author:
Li Zheng‐Jian1,
Wang Ming‐Yang1,
Li Chu‐Qiao1,
Zeng Wei‐Long1,
Li Wei1ORCID
Affiliation:
1. Department of Chemistry Zhejiang University 310027 Hangzhou China
Abstract
AbstractThe incorporation of the privileged amino functionality is of paramount importance in organic synthesis. In contrast to the well‐developed amination methods for alkenes, the dearomative amination of arenes is largely underexplored due to the inherently inert reactivity of arene π‐bonds and selectivity challenges. Herein, we report an intermolecular dearomative aminofunctionalization via direct nucleophilic addition of simple amines to chromium‐bound arenes. This multicomponent 1,2‐amination/carbonylation reaction enables rapid access to complicated alicyclic compounds containing amino and amide functionalities from benzene derivatives under CO‐gas‐free conditions, which also represents the first application of nitrogen‐based nucleophiles in η6‐coordination‐induced arene dearomatizations.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Subject
General Chemistry,Catalysis,Organic Chemistry
Reference111 articles.
1. For selected books see:
2. For a book see:
3. Modern Amination Methods
Cited by
1 articles.
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