Affiliation:
1. CEA INRAE Département Médicaments et Technologies pour la Santé (DMTS) SCBM Université Paris Saclay 91191 Gif-sur-Yvette France
2. LIONS NIMBE CEA CNRS Université Paris-Saclay 91191 Gif-sur-Yvette France
Abstract
AbstractRadiosensitive compounds can be useful for the detection of radiations and also as prodrugs that can be activated during a radiotherapy. Herein we describe the use of benzothiazolines, which upon treatment with 137Cs produced γ‐irradiation in water give rise to fluorescent benzothiazoles and concomitant release of amines or carboxylic acids. In a proof of concept study, we showed that benzothiazolines may be used as new cleavable linkers that can be triggered upon irradiation.
Subject
General Chemistry,Catalysis,Organic Chemistry
Cited by
1 articles.
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