Affiliation:
1. NSA Rouen UNIROUEN CNRS COBRA (UMR 6014) Normandie Univ. 76000 Rouen France
2. NovAliX, Campus de Maigremont BP615 27106 Val-de-Reuil CEDEX France
Abstract
AbstractHerein, we developed a photoinduced Minisci reaction on a large panel of diazines with good to excellent yields (28 examples, 44 % to 89 %). The reaction using 4CzIPN (1 mol %) as photoinitiator was carried out under white LED irradiation and required a slight excess of the acid reagent (1.2 equiv.). Cyclization reactions were then developed to access original N‐heterocycles building blocks for drug discovery programs. An extension of the reaction to continuous flow was also reported. Finally, the mechanism of the transformation was studied suggesting a plausible radical chain mechanism.
Funder
Agence Nationale de la Recherche
Subject
General Chemistry,Catalysis,Organic Chemistry