Affiliation:
1. Department of Chemistry Rutgers University 73 Warren Street Newark NJ 07102 United States
Abstract
AbstractSkeletal editing via single‐atom insertion reactions involving nitrogen heterocycles have been reported by two innovative and complementary methods for the conversion of pyrroles and indoles to pyridines, quinolines and quinazolines. The use of electrophilic carbonyl cation equivalents and in situ generated nitrenes enables molecular editing to transform heterocycles forming the foundation of best‐selling pharmaceuticals. Considering the importance of heterocycles in medicinal chemistry, biology and natural products, these methods offer innovative approach to complex molecular structures by heterocycle diversification and peripheral editing.
Subject
General Chemistry,Catalysis,Organic Chemistry
Cited by
23 articles.
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