Use of Conglomerate Mixed Crystals to Deracemize a Stable Racemic‐Compound‐Forming System

Abstract

AbstractDeracemization extended to racemic‐compound‐forming systems is demonstrated. We present here the first results of an alternative for the resolution of systems that exhibit a stable racemic compound but also a closely related conglomerate‐forming system. If the couples of enantiomers forming the racemic compound and the enantiomers of the stable conglomerate can syncrystallize in mirror‐related partial solid solutions, it is possible to deracemize the racemic mixture of mixed crystals to access to a single handedness. The evidence for this possibility is given in three examples by using temperature‐cycling‐induced deracemization.