Affiliation:
1. Key Laboratory of Food & Environment & Drug Monitoring and Testing of Universities in Hunan Province Hunan Police Academy Changsha 410138 China
2. Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology School of Chemistry and Chemical Engineering Liaocheng University Liaocheng, Shandong 252000 China
3. College of Chemistry and Materials Engineering Wenzhou University Wenzhou, Zhejiang 325035 China
4. School of Materials Science and Chemical Engineering Ningbo University Zhejiang 315211 China
Abstract
AbstractVinyl sulfones are crucial building blocks in synthetic chemistry and core structural units of pharmaceutically active molecules, thus extensive investigations have been conducted on the construction of these skeletons. In contrast to the classical synthetic approaches, the radical sulfonylation of alkynes for producing vinyl sulfones has garnered considerable interest because of its mild conditions and high efficiency. Radical sulfonation of alkynes typically begins with the sulfonyl radical attacking the alkynes, followed by further functionalization. Moreover, the association of metal‐catalyst‐free systems with multicomponent reactions (MCRs) offers an environmentally friendly pathway for efficiently constructing complex scaffolds from readily available partners. However, there is no comprehensive review summarizing the advancements in metal‐catalyst‐free multicomponent radical sulfonylation of alkynes. Hence, we provide a categorical overview based on the objects of sulfonylation of alkynes (hydrosulfonylation, carbosulfonylation, aminosulfonylation, oxysulfonylation, sulfosulfonylation, selenosulfonylation, and iodosulfonylation), along with interpretations of the reaction mechanisms.