Affiliation:
1. Faculty of Pharmaceutical Sciences Hokkaido University Kita-ku Sapporo 060-0812 Japan
2. Global Station for Biosurfaces and Drug Discovery Hokkaido University Kita-ku Sapporo 060-0812 Japan
Abstract
AbstractM‐HAT isomerization is a highly reliable method to access thermodynamically stable alkenes with high functional group tolerance. However, synthesis of heteroatom‐substituted alkenes by M‐HAT isomerization reaction is still underdeveloped. Herein, we report an enamide synthesis using M‐HAT via a combination of cobalt and photoredox catalysis. This method tolerates a variety of functional groups including haloarenes, heteroarenes, free hydroxy groups, non‐protected indoles, and drug derivatives. Furthermore, this method can isomerize styrene derivatives in good yield andE/Zselectivity.
Funder
Japan Society for the Promotion of Science
Subject
General Chemistry,Catalysis,Organic Chemistry
Cited by
7 articles.
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