Biological Evaluation of Isosteric Applicability of 1,3‐Substituted Cuneanes as m‐Substituted Benzenes Enabled by Selective Isomerization of 1,4‐Substituted Cubanes

Abstract

AbstractWe herein evaluate a biological applicability of 1,3‐substituted cuneanes as an isostere of m‐substituted benzenes based on its structural similarity. An investigation of a method to obtain 1,3‐substituted cuneanes by selective isomerization of 1,4‐substituted cubanes enables this attempt by giving a key synthetic step to obtain a cuneane analogs of pharmaceuticals having m‐substituted benzene moiety. Biological evaluation of the synthesized analogs and in silico study of the obtained result revealed a potential usage of cuneane skeleton in medicinal chemistry.