Affiliation:
1. Key Laboratory of Bioorganic Chemistry and Molecular Engineering Ministry of Education and Beijing National Laboratory for Molecular Science College of Chemistry and Molecular Engineering Peking University Beijing 100871 P. R. China
2. Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 (P. R. China) Institute of Molecular Physiology Shenzhen Bay Laboratory Shenzhen Guangdong 518055 P. R. China
Abstract
AbstractA general and practical approach for diverse dealkenylative functionalization of olefin‐containing substrates has been developed through the one‐pot formation and utilization of pro‐aromatic 1,4‐dihydropyridazines using tetrazine as the key cycloaddition reagent. Triggered by either excitation or oxidation, the targeted C−C bonds in the 1,4‐dihydropyridazine intermediates could be readily cleaved to generate alkyl radicals for subsequent transformations. Diverse carbon‐carbon and carbon‐hetero bond forming protocols, including Giese‐type addition, hydrazination, borylation, Minisci‐type alkylation, copper‐catalyzed NH alkylation, acylation, alkynylation, cyanation, and azidation, are achieved in a highly modular fashion.
Funder
National Natural Science Foundation of China
Beijing National Laboratory for Molecular Sciences
Shenzhen Bay Laboratory
Subject
General Chemistry,Catalysis,Organic Chemistry
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