Affiliation:
1. Key Laboratory of Bioorganic Chemistry and Molecular Engineering Ministry of Education and Beijing National Laboratory for Molecular Science College of Chemistry and Molecular Engineering Peking University Beijing 100871 P. R. China
2. Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 (P. R. China) Institute of Molecular Physiology Shenzhen Bay Laboratory Shenzhen Guangdong 518055 P. R. China
Abstract
AbstractA general and practical approach for diverse dealkenylative functionalization of olefin‐containing substrates has been developed through the one‐pot formation and utilization of pro‐aromatic 1,4‐dihydropyridazines using tetrazine as the key cycloaddition reagent. Triggered by either excitation or oxidation, the targeted C−C bonds in the 1,4‐dihydropyridazine intermediates could be readily cleaved to generate alkyl radicals for subsequent transformations. Diverse carbon‐carbon and carbon‐hetero bond forming protocols, including Giese‐type addition, hydrazination, borylation, Minisci‐type alkylation, copper‐catalyzed NH alkylation, acylation, alkynylation, cyanation, and azidation, are achieved in a highly modular fashion.
Funder
National Natural Science Foundation of China
Beijing National Laboratory for Molecular Sciences
Shenzhen Bay Laboratory
Subject
General Chemistry,Catalysis,Organic Chemistry
Reference112 articles.
1.
2. J.-D. Yang X.-S. Xue P. Ji X. Li J.-P. Cheng Internet Bond-energy Databank (pKa and BDE): iBonD Home Page http://ibond.chem.tsinghua.edu.cnorhttp://ibond.nankai.edu.cn(accessed 2022–10-01);
3. Comprehensive Handbook of Chemical Bond Energies
4. Recent advances in radical chemistry proceeding through pro-aromatic radicals
5.
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献