Cyclization, Decyclization, and Metallacyclization of Pyridine‐Substituted Homopropargylic Alcohols on Ruthenium(II) and Osmium(II) Centers

Abstract

AbstractSystematic investigations on the reactions between cis‐[M(dppm)2Cl2] (M=Ru/Os; dppm=1,1‐bis(diphenylphosphino)methane) and pyridine/quinoline substituted homopropargylic alcohols uncovered the diverse Ru(II)/Os(II)‐induced alkyne activation pathways. The alkynes underwent cyclization on M via a “non‐vinylidene” pathway at lower temperatures, resulting in alkenyl intermediates which might further metallacyclize to give metallapyrroloindolizines. Conversely, reactions at higher temperatures induced alkyne cyclization on M via a “vinylidene” pathway, affording cyclic oxacarbene complexes. Additionally, a rare decyclization mechanism was observed during the transformation of a metallacyclization‐resistant alkenyl complex into a cyclic oxacarbene complex. DFT calculations were employed to validate the experimental findings. Overall, these results not only provide insights into controlling alkyne activation pathways, but also offer new strategies for preparing metalated heterocyclic and metallacyclic complexes.