Stereoselective Synthesis of Polysubstituted Dihydropyrroles via 1,5‐Addition and <i>N</i>‐1,4‐Addition Cascade-Reference-Cited by-同舟云学术

Stereoselective Synthesis of Polysubstituted Dihydropyrroles via 1,5‐Addition and N‐1,4‐Addition Cascade

Published:2024-06-12 Issue:38 Volume:30 Page:
ISSN:0947-6539
Container-title:Chemistry – A European Journal
language:en
Short-container-title:Chemistry A European J

Author:

Zhang Jing‐Ming¹²,Wang Yu‐Chao²,Chen Liang¹²,Ma Chao²,He Zhi‐Tao¹²³^ORCID

Affiliation:

1. School of Chemistry and Materials Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences 310024 Hangzhou China

2. State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences 200032 Shanghai China

3. Ningbo Zhongke Creation Center of New Materials 315899 Ningbo China

Abstract

AbstractAn unprecedented 1,5‐addition/N‐1,4‐addition cascade reaction is established via palladium hydride catalysis. A variety of polysubstituted dihydropyrrole skeletons are constructed in high yield and with exclusively >20 : 1 diastereoselectivity. An enantioselective protocol of this design is also developed to provide a novel access to enantioenriched dihydropyrroles.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Natural Science Foundation of Ningbo Municipality

Publisher

Wiley

Reference64 articles.

2. Synthetic Strategies to Access Heteroatomic Spirocentres Embedded in Natural Products

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4. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

5. Recent developments and perspectives in the copper-catalyzed multicomponent synthesis of heterocycles

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