Affiliation:
1. Department of Chemistry University of Victoria P.O. Box 1700 Stn CSC Victoria BC V8W 2Y2 Canada
2. Department of Chemistry and Biochemistry University of Notre Dame Notre Dame IN 46556 USA
Abstract
AbstractA new type of diborate clathrochelate (cage) ligand featuring nine inwardly pointing nitrogen donors that form a large, rigid cavity, termed a mausolate, is presented. The cavity size and high denticity make this an attractive delivery vehicle for large radionuclides in nuclear medicine. Metal mausolate complexes are stable to air and water (neutral pH) and display extremely high thermal stability (>400 °C). Lanthanide uptake by the mausolate ligand occurs rapidly in solution at room temperature and once complexed, the lanthanide ions are not displaced by a 250‐fold excess of a competitive lanthanide salt over more than one week.