Affiliation:
1. School of Applied Sciences University of Huddersfield HD1 3DH Huddersfield UK
2. Axion BioSystems Vrijstraat 9B 5611 AT Eindhoven The Netherlands
Abstract
AbstractDipodal pyridylthiazole amine ligands L1 and L2 both form different metallo‐supramolecular self‐assemblies with Zn2+ and Cu2+ and these are shown to be toxic and selective towards cancer cell lines in vitro. Furthermore, potency and selectivity are highly dependent upon the metal ions, ligand system and bound anion, with significant changes in chemosensitivity and selectivity dependent upon which species are employed. Importantly, significant anti‐tumor activity was observed in ovo at doses that are non‐toxic.
Funder
Engineering and Physical Sciences Research Council
Subject
General Chemistry,Catalysis,Organic Chemistry