Affiliation:
1. College of Chemistry Liaoning University 110036 Shenyang Liaoning China
2. Judicial Authentication & Forensic Sciences Institute Liaoning University 110036 Shenyang Liaoning China
Abstract
AbstractThe formation of aromatic thioethers from C−S coupling is of great importance in synthetic chemistry. Traditional solution strategies through transition‐metal catalysis generally require bulk solution, heat, and longer reaction time. Herein, a mechano‐promoted sulfenylation of aryl iodides with nickel catalysis is described. The active aromatic sulfide agents are in‐situ generated from aromatic thiol or disulfide and subsequently adapted in the nickel catalytic cycle, with a tolerance of broad substituted groups under optimized conditions. In addition to the gram‐scale synthesis that reveals the application potential of the method, the radical trapping and competitive experiments are also conducted for the mechanistic study, thus providing a plausible mechanism rationally. Furthermore, the proposed methodology is certificated as being versatile and following the green principles with ideal calculated values of green chemistry metrics, and the comparison with other approaches for C−S bond formation is also demonstrated.
Funder
National Natural Science Foundation of China
Foundation of Liaoning Province Education Administration
Subject
General Chemistry,Catalysis,Organic Chemistry
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献