Affiliation:
1. School of Chemistry Dalian University of Technology Dalian 116024 P. R. China
2. Key Laboratory of Green Chemistry & Technology Ministry of Education College of Chemistry Sichuan University Chengdu 610064 P. R. China
Abstract
AbstractTetrahydropyridazines constitute an important structural motif found in numerous natural products and pharmaceutical compounds. Herein, we report an aminoacylation reaction of alkenes that enables the synthesis of 1,4,5,6‐tetrahydropyridazines through cooperative N‐heterocyclic carbene (NHC) and photoredox catalysis. This approach involves the 6‐endo‐trig cyclization of N‐centered hydrazonyl radicals, generated via single‐electron oxidation of hydrazones, followed by a radical–radical coupling step. The mild process tolerates a wide range of common functional groups and affords a variety of tetrahydropyridazines in moderate to high yields. Preliminary investigations using chiral NHC catalysts demonstrate the potential of this protocol for asymmetric radical reactions.