Affiliation:
1. Department of Chemistry University of Florida Gainesville Florida 32611 United States
2. College of Chemistry and Chemical Engineering Shandong University of Technology 266 West Xincun Road Zibo 255000 China
Abstract
Abstract1,1,2,2‐Tetrafluoroethyl‐containing compounds are valuable structures due to their unique physicochemical properties, which have increasing potential application in drug discovery. However, synthetic methods for preparing such compounds are rare. Herein, we report the first use of 1,1,2,2‐tetrafluoroethanesulfonyl chloride to introduce the HCF2CF2 group into organic molecules via a three‐component, radical tetrafluoroethyl‐heteroarylation of alkenes with readily available quinoxalin‐2(1H)‐ones. This method provides a new and facile approach for late‐stage functionalization of potential biologically active molecules.
Subject
General Chemistry,Catalysis,Organic Chemistry