Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs

Author:

Kolosenko Iryna1,Fryknäs Mårten2,Forsberg Sofi1,Johnsson Per1,Cheon HyeonJoo3,Holvey-Bates Elise G.3,Edsbäcker Elin1,Pellegrini Paola1,Rassoolzadeh Hanif1,Brnjic Slavica1,Larsson Rolf2,Stark George R.3,Grandér Dan1,Linder Stig1,Tamm Katja Pokrovskaja1,De Milito Angelo1

Affiliation:

1. Department of Oncology-Pathology, Cancer Center Karolinska; Karolinska Institutet; 17176 Stockholm Sweden

2. Division of Clinical Pharmacology, Department of Medical Sciences; Uppsala University Hospital; 751 85 Uppsala Sweden

3. Department of Molecular Genetics; Lerner Research Institute, Cleveland Clinic; Cleveland OH

Funder

Cancerfonden

Swedish Research Council Formas

Association for International Cancer Research

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference42 articles.

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2. Limited penetration of anticancer drugs through tumor tissue: a potential cause of resistance of solid tumors to chemotherapy;Tannock;Clin Cancer Res,2002

3. Repopulation of cancer cells during therapy: an important cause of treatment failure;Kim;Nat Rev Cancer,2005

4. Accumulation and distribution of doxorubicin in tumour spheroids: the influence of acidity and expression of P-glycoprotein;Mellor;Cancer Chemother Pharmacol,2011

5. The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths;Swietach;J Biol Chem,2009

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