Development and validation of a liquid chromatography-tandem mass spectrometry analytical method for the therapeutic drug monitoring of eight novel anticancer drugs

Author:

Herbrink M.1ORCID,de Vries N.1,Rosing H.1,Huitema A. D. R.12,Nuijen B.1,Schellens J. H. M.13,Beijnen J. H.13

Affiliation:

1. Department of Pharmacy and Pharmacology; The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital and MC Slotervaart; Amsterdam The Netherlands

2. Department of Clinical Pharmacy; University Medical Center Utrecht; Utrecht The Netherlands

3. Division of Pharmacoepidemiology and Clinical Pharmacology, Science Faculty, Utrecht Institute for Pharmaceutical Sciences; Utrecht University; Utrecht The Netherlands

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference28 articles.

1. European Medicines Agency 2015 Assessment Report Zykadia (EPAR) http://www.ema.europa.eu/ema/

2. European Medicines Agency, & Use, Committee for Medicinal Products for Human Use (CHMP). 2011 Guidelines on Bioanalytical Method Validation http://www.ema.europa.eu/ema/

3. Dose selection, pharmacokinetics, and pharmacodynamics of BRAF inhibitor dabrafenib (GSK2118436);Falchook;Clinical Cancer Research,2014

4. Evidence for therapeutic drug monitoring of targeted anticancer therapies;Gao;Journal of Clinical Oncology,2012

5. Quantification of 11 therapeutic kinase inhibitors in human plasma for therapeutic drug monitoring using liquid chromatography coupled with tandem mass spectrometry;Herbrink;Therapeutic Drug Monitoring,2016

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