Nutlin-3 treatment spares cisplatin-induced inhibition of bone healing while maintaining osteosarcoma toxicity

Author:

Stine Kimo C.1,Wahl Elizabeth C.2,Liu Lichu2,Skinner Robert A.3,VanderSchilden Jaclyn3,Bunn Robert C.1,Montgomery Corey O.3,Aronson James123,Becton David L.1,Nicholas Richard W.3,Swearingen Christopher J.14,Suva Larry J.3,Lumpkin Charles K.12

Affiliation:

1. Departments of Pediatrics; University of Arkansas for Medical Sciences; Arkansas

2. Laboratory for Limb Regeneration Research; Arkansas Children's Hospital Research Institute; Arkansas

3. Department of Orthopaedic Surgery; Center for Orthopaedic Research; University of Arkansas for Medical Sciences; Little Rock Arkansas

4. Pediatric Biostatistics; Arkansas Children's Hospital Research Institute; Arkansas

Funder

Children's University Medical Group Fund Grant Program

Arkansas Biosciences Institute

UAMS Pediatric Hematology/Oncology Division

National Institutes of Health National Center for Research Resources

NIH National Center for Research Resources

National Institutes of Health

Publisher

Wiley

Subject

Orthopedics and Sports Medicine

Reference51 articles.

1. Effects on bone metabolism of new therapeutic strategies with standard chemotherapy and biologic drugs. 2013;Ciolli;Clin Cases Miner Bone Metab

2. The kinase Mirk is a potential therapeutic target in osteosarcoma;Yang;Carcinogenesis,2010

3. Osteosarcoma;Messerschmitt;J Am Acad Orthop Surg,2009

4. Low bone mineral density and high incidences of fractures and vitamin D deficiency in 52 pediatric cancer survivors;Bilariki;Horm Res Paediatric,2010

5. Emerging drugs for the management of cancer treatment induced bone loss;Bertoldo;Expert Opin Emerg Drugs,2010

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