An Efficient Exogenous Gene Insertion Site in CHO Cells with High Transcription Level to Enhance AID‐Induced Mutation-Reference-Cited by-同舟云学术

An Efficient Exogenous Gene Insertion Site in CHO Cells with High Transcription Level to Enhance AID‐Induced Mutation

Published:2020-02-06 Issue:5 Volume:15 Page:1900313
ISSN:1860-6768
Container-title:Biotechnology Journal
language:en
Short-container-title:Biotechnol. J.

Author:

Fan Yingjun¹²,Jiang Wei¹²,Ran Fanlei¹,Luo Ruiqi¹²,An Lili¹,Hang Haiying¹^ORCID

Affiliation:

1. Key Laboratory of Protein and Peptide DrugsNational Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academy of Sciences Beijing 100101 China

2. College of Life SciencesUniversity of Chinese Academy of Sciences Beijing 100049 China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/biot.201900313

Reference36 articles.

1. Beyond natural antibodies: the power of in vitro display technologies

2. Affinity maturation of anti-TNF-alpha scFv with somatic hypermutation in non-B cells

3. The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells

4. Mammalian cell display for the discovery and optimization of antibody therapeutics

5. High Affinity Humanized Antibodies without Making Hybridomas; Immunization Paired with Mammalian Cell Display and In Vitro Somatic Hypermutation

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